Identification of a novel cis-regulatory element essential for immune tolerance
نویسندگان
چکیده
منابع مشابه
Identification of a novel cis-regulatory element essential for immune tolerance
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tolerize self-reactive thymocytes. Interestingly, Aire has a highly tissue-restricted pattern of exp...
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Upon fertilization Chlamydomonas reinhardtii zygotes undergo a program of differentiation into a diploid zygospore that is accompanied by transcription of hundreds of zygote-specific genes. We identified a distinct sequence motif we term a zygotic response element (ZYRE) that is highly enriched in promoter regions of C reinhardtii early zygotic genes. A luciferase reporter assay was used to sho...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2015
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20151069